Available Modifications:

• Acetylation, acylation (e.g. lipopeptides), biotinylation and formylation

• Amidation

• Thioethers, hydroxyethylene isosteres, retro-inverso peptides

• Cyclizations: single or multiple disulfide bridges, head to tail and side chain (lactam bridge, thioether)

• Phosphorylation, sulfation and glycosylation

• Incorporation of chromophores

• Fluorescent dyes/fluorogenic groups

• Fluorophore/quencher pairs

• Conjugation to a carrier protein

• Incorporation of D-enantiomers and unusual amino acids

• Labeling with stable isotopes and radiolabeling

• Introduction of C-terminal alcohol moieties

• Introduction of C-terminal ester and thioester groups

• Depsipeptides

• Stabilizing modifications including PEGylation, N-methylated amino acids and reduced peptide bonds

• Ligations

• Hydrocarbon-stapled peptides

• Conjugation of cytotoxic molecules

• Incorporation of chelating moieties (DOTA, DPTA)